NR1H4

Gene

nuclear receptor subfamily 1 group H member 4

HGNCHGNC:7967 EnsemblENSG00000012504 NCBI Gene9971

Locus: gene with protein productLocation: 12q23.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Bile acid receptorQ96RI1

Protein · therapeutic target

Clinically validated target · 3 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asFXR · RIP14 · HRR1 · HRR-1

View full nomenclature history (7)

Alias symbolsFXR, RIP14, HRR1, HRR-1

Previous namesnuclear receptor subfamily 1, group H, member 4

Alias namesfarnesoid X receptor, bile acid receptor

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Progressive familial intrahepatic cholestasis

Primary biliary cholangitis

Biliary liver cirrhosis

Progressive familial intrahepatic cholestasis type 1

Ciliopathy

Cerebrotendinous xanthomatosis

Hepatitis C, Chronic

Cholelithiasis

Cholangitis

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Nuclear receptor subfamily 1 group H

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.