Back to discover

ATP8B1

Gene

ATPase phospholipid transporting 8B1

HGNCHGNC:3706EnsemblENSG00000081923NCBI Gene5205
Locus: gene with protein productLocation: 18q21.31

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asFIC1 · BRIC · PFIC1 · ATPIC · PFIC
View full nomenclature history (8)
Previous symbolsFIC1, BRIC, PFIC1
Alias symbolsATPIC, PFIC
Previous namesATPase, Class I, type 8B, member 1, ATPase, aminophospholipid transporter, class I, type 8B, member 1
Alias namesphospholipid-transporting ATPase IC

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Progressive familial intrahepatic cholestasis type 1
Progressive familial intrahepatic cholestasis
Cholestasis, Intrahepatic
Genetic Diseases, Inborn
Corneal Dystrophies, Hereditary
Fuchs' Endothelial Dystrophy

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

ATPase phospholipid transporting

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2025-10-09.
Open TargetsGene–disease associations from the Open Targets Platform.