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Disease

Fuchs' Endothelial Dystrophy

Late-stage therapeutic developmentEmerging research
MeSHFuchs' Endothelial Dystrophy
1
Publications
13
Clinical trials
12
Associated genes
2
Related proteins
2016
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 3 clinical trials expected to report results, the earliest in Q4 2027.
Upcoming Milestones
Major developments
Upcoming trial readoutHigh impact
Descemet Endothelial Thickness Comparison Trials (DETECT I & II)
Results expected Q4 20272026-05-08
Upcoming trial readoutImportant
Safety and Efficacy of Brief Intraoperative Corneal Endothelial Graft Incubation in Plasma Rich in Growth Factors (PRGF) for Reducing Postoperative Endothelial Cell Loss
Results expected Q4 20272026-04-09
Clinical Milestones4View
Results expected 3
Recently completed 1
Activity timeline4

Clinical trials

11 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
13
All trials
6
Active
7
Late-stage
5
Completed
Late-stage studies

Optimized Immunosuppression for Corneal Transplantation: A Multi-center Randomized Controlled Clinical Trial

Phase 4 · Recruiting · Maastricht University Medical Center

A Pilot Study For Efficacy And Safety Of Glanatec® Opthalmic Solution 0.4% On Corneal Edema And Endothelial Cell Counts In Subjects With Fuchs Endothelial Dystrophy Undergoing Descemet Stripping Without Endothelial Keratoplasty

Phase 4 · Recruiting · Marian Macsai, MD

Descemet Endothelial Thickness Comparison Trials (DETECT I & II)

Phase 3 · Recruiting · Stanford University

The Effects of Ripasudil in Patients With Fuchs Endothelial Corneal Dystrophy Undergoing Femtosecond Laser Assisted Cataract Surgery

Phase 3 · Recruiting · Singapore Eye Research Institute

Randomized, Double-masked, Placebo-controlled Evaluation of Netarsudil for Prevention of Corticosteroid-induced Intraocular Pressure Elevation

Phase 3 · Completed · Cornea Research Foundation of America

Prospective Randomized Study to Determine Whether Use of Rhopressa™ Accelerates Corneal Clearing After Removal of Descemet Membrane for Treatment of Fuchs Dystrophy

Phase 2/3 · Terminated · Price Vision Group
Recruiting

Optimized Immunosuppression for Corneal Transplantation: A Multi-center Randomized Controlled Clinical Trial

Phase 4 · Recruiting · Maastricht University Medical Center

A Pilot Study For Efficacy And Safety Of Glanatec® Opthalmic Solution 0.4% On Corneal Edema And Endothelial Cell Counts In Subjects With Fuchs Endothelial Dystrophy Undergoing Descemet Stripping Without Endothelial Keratoplasty

Phase 4 · Recruiting · Marian Macsai, MD

Descemet Endothelial Thickness Comparison Trials (DETECT I & II)

Phase 3 · Recruiting · Stanford University

The Effects of Ripasudil in Patients With Fuchs Endothelial Corneal Dystrophy Undergoing Femtosecond Laser Assisted Cataract Surgery

Phase 3 · Recruiting · Singapore Eye Research Institute

Phase 1, Multiple Dose, Open-Label Study to Assess the Safety and Tolerability of EO2002 Intracameral Injections With or Without Topical Ripasudil in the Treatment of Corneal Edema

Phase 1 · Recruiting · Asociación para Evitar la Ceguera en México

Safety and Efficacy of Brief Intraoperative Corneal Endothelial Graft Incubation in Plasma Rich in Growth Factors (PRGF) for Reducing Postoperative Endothelial Cell Loss

N/A · Recruiting · University of Miami
Recently completed

Prospective Assessment of Whether Adjuvant Netarsurdil Use Improves Post-Operative Outcomes in Patients Undergoing Descemetorhexis Without Endothelial Keratoplasty

Early Phase 1 · Completed · Massachusetts Eye and Ear Infirmary

Phase 2 Study To Determine the Safety and Efficacy of TTHX1114(NM141) on the Regeneration and Migration of Corneal Endothelial Cells in Patients Undergoing DWEK/DSO

Phase 2 · Completed · Trefoil Therapeutics, Inc.

Netarsudil Use After Descemetorhexis Without Endothelial Keratoplasty

Early Phase 1 · Completed · Massachusetts Eye and Ear Infirmary

Randomized, Double-masked, Placebo-controlled Evaluation of Netarsudil for Prevention of Corticosteroid-induced Intraocular Pressure Elevation

Phase 3 · Completed · Cornea Research Foundation of America

Immunosuppression During Penetrating Keratoplasty, Using a Subconjunctival Implant Releasing Dexamethasone: Tolerance and Safety Pilot Study

Phase 2 · Completed · Centre Hospitalier Universitaire de Saint Etienne

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Major themes1
  • Oxidative Stress1
Leading journals1
  • Oxidative medicine and cellular longevity1
Leading researchers2
  • Grzybowski A1
  • Nita M1
Affiliations (unnormalised)2
  • Domestic and Specialized Medicine Centre "Dilmed"1
  • Poznan City Hospital1

Associated genes

12 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

COL8A20.77ZEB10.75SLC4A110.62TCF40.62AGBL10.62LAMC10.46KANK40.43ATP1B10.43LAMB10.42RAB27B0.42ROCK20.40ROCK10.39

Disease biology

2 matches

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Zinc finger E-box-binding homeobox 1via ZEB10.75Sodium/potassium-transporting ATPase subunit beta-1via ATP1B10.43

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Disorder caused by loss of endothelium of the central cornea. It is characterized by hyaline endothelial outgrowths on Descemet's membrane, epithelial blisters, reduced vision, and pain.

Identifiers
MeSHFuchs' Endothelial Dystrophy
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.