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TCF4

Gene

transcription factor 4

HGNCHGNC:11634EnsemblENSG00000196628NCBI Gene6925
Locus: gene with protein productLocation: 18q21.2

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asSEF2-1B · ITF2 · bHLHb19 · E2-2
View full nomenclature history (7)
Alias symbolsSEF2-1B, ITF2, bHLHb19, E2-2
Alias namesSL3-3 enhancer factor 2, class B basic helix-loop-helix protein 19, immunoglobulin transcription factor 2

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Fuchs' Endothelial Dystrophy
Genetic Diseases, Inborn
Major depressive disorder
Autism Spectrum Disorder
Schizophrenia

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Basic helix-loop-helix proteins

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-15.
Open TargetsGene–disease associations from the Open Targets Platform.