ZEB1

Gene

zinc finger E-box binding homeobox 1

HGNCHGNC:11642 EnsemblENSG00000148516 NCBI Gene6935

Locus: gene with protein productLocation: 10p11.22

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Zinc finger E-box-binding homeobox 1P37275

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asTCF8 · PPCD3 · BZP · ZEB · AREB6 · NIL-2-A · Zfhep · Zfhx1a · FECD6

View full nomenclature history (11)

Previous symbolsTCF8, PPCD3

Alias symbolsBZP, ZEB, AREB6, NIL-2-A, Zfhep, Zfhx1a, FECD6

Previous namesposterior polymorphous corneal dystrophy 3, transcription factor 8 (represses interleukin 2 expression)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Fuchs' Endothelial Dystrophy

Genetic Diseases, Inborn

Corneal Dystrophies, Hereditary

Neurodegenerative Diseases

Glaucoma

Ovarian dysfunction

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Zinc fingers C2H2-typeZF class homeoboxes and pseudogenes

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.