AFF3

Gene

ALF transcription elongation factor 3

HGNCHGNC:6473 EnsemblENSG00000144218 NCBI Gene3899

Locus: gene with protein productLocation: 2q11.2

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asLAF4 · MLLT2-like

View full nomenclature history (5)

Previous symbolsLAF4

Alias symbolsMLLT2-like

Previous nameslymphoid nuclear protein related to AF4, AF4/FMR2 family, member 3, AF4/FMR2 family member 3

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Arthritis, Rheumatoid

Intelligence

Genetic Diseases, Inborn

Diabetes Mellitus, Type 1

Gastroesophageal Reflux

Smoking initiation

Gastric carcinoma

Lung carcinoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

AF4/FMR2 familySuper elongation complex

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.