AKR1C2

Gene

aldo-keto reductase family 1 member C2

HGNCHGNC:385 EnsemblENSG00000151632 NCBI Gene1646

Locus: gene with protein productLocation: 10p15.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asDDH2 · TDD · DD · BABP · DD2 · HAKRD · MCDR2

View full nomenclature history (10)

Previous symbolsDDH2, TDD

Alias symbolsDD, BABP, DD2, HAKRD, MCDR2

Previous namesaldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III), testicular 17,20-desmolase deficiency

Alias namesdihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

46,XY disorder of sex development due to isolated 17,20 lyase deficiency

Neurodegenerative Diseases

Bipolar Disorder

Breast Neoplasms

Esophageal Squamous Cell Carcinoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Aldo-keto reductases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.