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AKR1C4

Gene

aldo-keto reductase family 1 member C4

HGNCHGNC:387EnsemblENSG00000198610NCBI Gene1109
Locus: gene with protein productLocation: 10p15.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCHDR · DD4 · HAKRA · C11 · 3-alpha-HSD · CDR · MGC22581
View full nomenclature history (11)
Previous symbolsCHDR
Alias symbolsDD4, HAKRA, C11, 3-alpha-HSD, CDR, MGC22581
Previous namesaldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
Alias nameschlordecone reductase, 3-alpha hydroxysteroid dehydrogenase, type I, dihydrodiol dehydrogenase 4

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

46,XY disorder of sex development due to isolated 17,20 lyase deficiency
Hypogonadism
Deafness
Hearing loss, autosomal recessive
Kartagener Syndrome

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Aldo-keto reductases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.