ALK

Gene

ALK receptor tyrosine kinase

HGNCHGNC:427 EnsemblENSG00000171094 NCBI Gene238

Locus: gene with protein productLocation: 2p23.2-p23.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

ALK tyrosine kinase receptorQ9UM73

Protein · therapeutic target

Clinically validated target · 7 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCD246 · ALK1

View full nomenclature history (4)

Alias symbolsCD246, ALK1

Previous namesanaplastic lymphoma kinase (Ki-1), anaplastic lymphoma receptor tyrosine kinase

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neuroblastoma

Neuroblastoma, susceptibility to, 3

Carcinoma, Non-Small-Cell Lung

Neoplasms

Lung Neoplasms

Anaplastic large cell lymphoma

Adenocarcinoma of Lung

Squamous cell lung carcinoma

Lymphoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD moleculesALK and LTK receptor tyrosine kinase family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.