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ANKLE2

Gene

ankyrin repeat and LEM domain containing 2

HGNCHGNC:29101EnsemblENSG00000176915NCBI Gene23141
Locus: gene with protein productLocation: 12q24.33

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asLEMD7 · Lem4
View full nomenclature history (5)
Alias symbolsLEMD7, Lem4
Previous namesKIAA0692
Alias namesLEM domain containing 7, LEM-domain protein 4

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Autosomal recessive primary microcephaly
Neurodegenerative Diseases
Microcephaly
Genetic Diseases, Inborn
Leukoencephalopathies
Diabetes Mellitus

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Ankyrin repeat domain containingLEM domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.