Microcephaly
Recent clinical, regulatory, research and industry developments relating to this disease.
Lithium normalizes ASD-related neuronal, synaptic, and behavioral phenotypes in DYRK1A-knockin mice.
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
- 1 clinical trial expected to report results, the earliest in Q4 2028.
Clinical MilestonesViewHide
Clinical trials
The current development programme across all trial phases.
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Major themes8
- Autism Spectrum Disorder1
- Intellectual Disability1
- Lithium1
- Mutation1
- Neurodevelopmental Disorders1
- Protein Serine-Threonine Kinases1
- Protein-Tyrosine Kinases1
- RNA, Small Nuclear1
Leading journals2
- Molecular psychiatry1
- Nature medicine1
Leading researchers8
- Bae M1
- Bae YC1
- Berry IR1
- Cho Y1
- Ellegood J1
- Freson K1
- Greene D1
- Jang H1
Affiliations (unnormalised)6
- Bloorview Research Institute1
- Bristol Medical School1
- Center for Molecular and Vascular Biology1
- Center for Synaptic Brain Dysfunctions1
- Charles Bronfman Institute for Personalized Medicine1
- Clinical Genetics Unit1
Associated genes
Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.
Disease biology
Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.
Reference
Authoritative identity, definition & identifiers.
A congenital abnormality in which the CEREBRUM is underdeveloped, the fontanels close prematurely, and, as a result, the head is small. (Desk Reference for Neuroscience, 2nd ed.)
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.