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SMG8

Gene

SMG8 nonsense mediated mRNA decay factor

HGNCHGNC:25551EnsemblENSG00000167447NCBI Gene55181
Locus: gene with protein productLocation: 17q22

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asC17orf71 · FLJ10587 · FLJ23205
View full nomenclature history (6)
Previous symbolsC17orf71
Alias symbolsFLJ10587, FLJ23205
Previous nameschromosome 17 open reading frame 71, smg-8 homolog, nonsense mediated mRNA decay factor (C. elegans), SMG8, nonsense mediated mRNA decay factor

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Microcephaly
Neurodegenerative Diseases
Alzheimer's Disease
Multiple Sclerosis
Parkinson's Disease

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

SMG1 complex

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.