ASPM

Gene

assembly factor for spindle microtubules

HGNCHGNC:19048 EnsemblENSG00000066279 NCBI Gene259266

Locus: gene with protein productLocation: 1q31.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asMCPH5 · Calmbp1 · ASP · FLJ10517 · FLJ10549

View full nomenclature history (9)

Previous symbolsMCPH5

Alias symbolsCalmbp1, ASP, FLJ10517, FLJ10549

Previous namesmicrocephaly, primary autosomal recessive 5, asp (abnormal spindle)-like, microcephaly associated (Drosophila), asp (abnormal spindle) homolog, microcephaly associated (Drosophila), abnormal spindle microtubule assembly

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Autosomal recessive primary microcephaly

Genetic Diseases, Inborn

Microcephaly 1, primary, autosomal recessive

Microcephaly

Macular Degeneration

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.