APPL1

Gene

adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1

HGNCHGNC:24035 EnsemblENSG00000157500 NCBI Gene26060

Locus: gene with protein productLocation: 3p14.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asAPPL

View full nomenclature history (3)

Alias symbolsAPPL

Previous namesadaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1

Alias namesDCC-interacting protein 13-alpha

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

MODY

Neurodegenerative Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

BAR-PH domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.