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ARHGEF12

Gene

Rho guanine nucleotide exchange factor 12

HGNCHGNC:14193EnsemblENSG00000196914NCBI Gene23365
Locus: gene with protein productLocation: 11q23.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asKIAA0382 · LARG
View full nomenclature history (3)
Alias symbolsKIAA0382, LARG
Previous namesRho guanine nucleotide exchange factor (GEF) 12

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Glaucoma
Glaucoma, Open-Angle
Lung carcinoma
Carcinoma of liver and intrahepatic biliary tract
Carcinoma, Ductal, Breast
Lymphoid neoplasm

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Dbl family Rho GEFsPDZ domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.