ATR

Gene

ATR checkpoint kinase

HGNCHGNC:882 EnsemblENSG00000175054 NCBI Gene545

Locus: gene with protein productLocation: 3q23

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Serine/threonine-protein kinase ATRQ13535

Protein · therapeutic target

Clinical-stage target · 4 candidates in clinical development

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asFRP1 · SCKL · SCKL1 · MEC1

View full nomenclature history (6)

Alias symbolsFRP1, SCKL, SCKL1, MEC1

Previous namesataxia telangiectasia and Rad3 related

Alias namesMEC1, mitosis entry checkpoint 1, homolog (S. cerevisiae)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Seckel syndrome 1

Familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndrome

Seckel syndrome

Microcephalic primordial dwarfism

Genetic Diseases, Inborn

Neurodegenerative Diseases

Carcinoma, Non-Small-Cell Lung

Lung carcinoma

Prostate carcinoma

Skin squamous cell carcinoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Armadillo like helical domain containingPhosphatidylinositol 3-kinase-related kinase family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2025-03-27.

Open TargetsGene–disease associations from the Open Targets Platform.