BCL2

Gene

BCL2 apoptosis regulator

HGNCHGNC:990 EnsemblENSG00000171791 NCBI Gene596

Locus: gene with protein productLocation: 18q21.33

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Apoptosis regulator Bcl-2P10415

Protein · therapeutic target

Clinically validated target · 3 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asBcl-2 · PPP1R50

View full nomenclature history (5)

Alias symbolsBcl-2, PPP1R50

Previous namesB-cell CLL/lymphoma 2, BCL2, apoptosis regulator

Alias namesprotein phosphatase 1, regulatory subunit 50

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Leukemia, Lymphocytic, Chronic, B-Cell

Neoplasms

Lymphoma, Large B-Cell, Diffuse

Neurodegenerative Diseases

Leukemia, Myeloid, Acute

Multiple Myeloma

Prostate carcinoma

Diabetes Mellitus, Type 2

Leukemia, Lymphoid

Lymphoid neoplasm

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Protein phosphatase 1 regulatory subunitsBCL2 family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-07-25.

Open TargetsGene–disease associations from the Open Targets Platform.