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Disease

Leukemia, Lymphoid

Active therapeutic pipelineEmerging research
MeSHLeukemia, Lymphoid
1
Publications
5
Clinical trials
12
Associated genes
4
Related proteins
1966
Latest publication
Current focus
Perforin-1 biologyTherapeutic developmentInflammation & immunityDisease mechanisms & pathology
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial expected to report results, the earliest in Q3 2032.
Upcoming Milestones
Clinical Milestones2View
Results posted 1
Results expected 1
Activity timeline2

Clinical trials

5 sponsors · 0 new · 1 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
5
All trials
1
Active
0
Late-stage
4
Completed
Recently completed

A Phase 2 Study of Oral LOXO-305 in Patients With Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) or Non-Hodgkin Lymphoma (NHL)

Phase 2 · Completed · Eli Lilly and Company

Dasatinib Plus Multi-agent Chemotherapy for New Diagnosed Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia

Phase 2 · Completed · Institute of Hematology & Blood Diseases Hospital, China

A Pilot Trial Examining Myeloid-Derived Suppressor Cells and Checkpoint Immune Regulators' Expression in Allogeneic Stem Cell Transplant Recipients Using Myeloablative Busulfan and Fludarabine

Phase 1 · Completed · Dartmouth-Hitchcock Medical Center

A Phase II, Multi-center, Open-label, Repeat-dose Study of Lenalidomide (Revlimid ®) Plus Low-dose Dexamethasone in Patients With Refractory B Cell Lineage Acute Lymphoblastic Leukemia or in Relapse After 2 Lines of Treatment

Phase 2 · Completed · Institut de Cancérologie de la Loire

Research activity

1 paper

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Major themes3
  • Leukocyte Count1
  • Leukopenia1
  • Lymphocytes1
Leading journals1
  • Annals of internal medicine1
Leading researchers4
  • Bodey GP1
  • Buckley M1
  • Freireich EJ1
  • Sathe YS1

Associated genes

12 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

NOTCH10.58CHD20.56SF3B10.56MYD880.52PRF10.51BCL20.49ACTA20.47ACOXL0.47SP1400.45GRAMD1B0.45BMF0.43C11orf210.42

Disease biology

4 matches

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Perforin-1via PRF10.51Apoptosis regulator Bcl-2via BCL20.49Tyrosine-protein kinase Lynvia LYN0.41Large ribosomal subunit protein P1via RPLP10.35

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Leukemia associated with HYPERPLASIA of the lymphoid tissues and increased numbers of circulating malignant LYMPHOCYTES and lymphoblasts.

Identifiers
MeSHLeukemia, Lymphoid
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.