SF3B1

Gene

splicing factor 3b subunit 1

HGNCHGNC:10768 EnsemblENSG00000115524 NCBI Gene23451

Locus: gene with protein productLocation: 2q33.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asSAP155 · SF3b155 · PRPF10 · Prp10 · Hsh155

View full nomenclature history (7)

Alias symbolsSAP155, SF3b155, PRPF10, Prp10, Hsh155

Previous namessplicing factor 3b, subunit 1, 155kD, splicing factor 3b, subunit 1, 155kDa

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Leukemia, Lymphocytic, Chronic, B-Cell

Myelodysplastic syndrome

Leukemia, Lymphoid

Myeloproliferative disorder

Breast adenocarcinoma

Neurodegenerative Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Armadillo like helical domain containingSF3b complexB-WICH chromatin-remodelling complex subunits

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.