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NOTCH1

Gene

notch receptor 1

HGNCHGNC:7881EnsemblENSG00000148400NCBI Gene4851
Locus: gene with protein productLocation: 9q34.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asTAN1
View full nomenclature history (4)
Previous symbolsTAN1
Previous namesNotch (Drosophila) homolog 1 (translocation-associated), Notch homolog 1, translocation-associated (Drosophila), notch 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Leukemia, Lymphocytic, Chronic, B-Cell
Aortic Valve Stenosis
Neoplasms
Squamous Cell Carcinoma of Head and Neck
Leukemia, Lymphoid
Neurodegenerative Diseases
Squamous cell lung carcinoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Notch receptorsMicroRNA protein coding host genes

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.