BIRC2

Gene

baculoviral IAP repeat containing 2

HGNCHGNC:590 EnsemblENSG00000110330 NCBI Gene329

Locus: gene with protein productLocation: 11q22.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Baculoviral IAP repeat-containing protein 2Q13490

Protein · therapeutic target

Clinical-stage target · 1 candidate in clinical development

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asAPI1 · cIAP1 · hiap-2 · MIHB · RNF48 · c-IAP1

View full nomenclature history (9)

Previous symbolsAPI1

Alias symbolscIAP1, hiap-2, MIHB, RNF48, c-IAP1

Previous namesbaculoviral IAP repeat-containing 2

Alias namesNFR2-TRAF signalling complex protein, apoptosis inhibitor 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases

Pre-Eclampsia

Neoplasms

Carcinoma, Hepatocellular

Squamous Cell Carcinoma of Head and Neck

Ovarian Neoplasms

Carcinoma, Non-Small-Cell Lung

Cholangiocarcinoma

Breast Neoplasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Ring finger proteinsBaculoviral IAP repeat containingCaspase recruitment domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.