BIRC3

Gene

baculoviral IAP repeat containing 3

HGNCHGNC:591 EnsemblENSG00000023445 NCBI Gene330

Locus: gene with protein productLocation: 11q22.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Baculoviral IAP repeat-containing protein 3Q13489

Protein · therapeutic target

Clinical-stage target · 1 candidate in clinical development

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asAPI2 · cIAP2 · hiap-1 · MIHC · RNF49 · MALT2 · c-IAP2

View full nomenclature history (12)

Previous symbolsAPI2

Alias symbolscIAP2, hiap-1, MIHC, RNF49, MALT2, c-IAP2

Previous namesbaculoviral IAP repeat-containing 3

Alias namesapoptosis inhibitor 2, TNFR2-TRAF signaling complex protein, mammalian IAP homolog C, inhibitor of apoptosis protein 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Leukemia, Lymphocytic, Chronic, B-Cell

Crohn's Disease

Lymphoma, Mantle-Cell

Multiple Myeloma

Cutaneous melanoma

Lymphoid neoplasm

Skin squamous cell carcinoma

Squamous cell lung carcinoma

Carcinoma, Hepatocellular

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Ring finger proteinsBaculoviral IAP repeat containingCaspase recruitment domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.