BRK1

Gene

BRICK1 subunit of SCAR/WAVE actin nucleating complex

HGNCHGNC:23057 EnsemblENSG00000254999 NCBI Gene55845

Locus: gene with protein productLocation: 3p25.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asC3orf10 · MDS027 · HSPC300

View full nomenclature history (8)

Previous symbolsC3orf10

Alias symbolsMDS027, HSPC300

Previous nameschromosome 3 open reading frame 10, BRICK1, SCAR/WAVE actin-nucleating complex subunit, BRICK1, SCAR/WAVE actin nucleating complex subunit

Alias namesBRICK1, SCAR/WAVE actin-nucleating complex subunit, homolog (Arabidopsis thaliana), haematopoietic stem/progenitor cell protein 300

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases

Kidney Neoplasms

Urinary Bladder Neoplasms

Neoplasms

Carcinoma, Non-Small-Cell Lung

Carcinoma, Renal Cell

Pulmonary Disease, Chronic Obstructive

Neuroblastoma

Squamous cell lung carcinoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

SCAR/WAVE complex

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.