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C3

Gene

complement C3

HGNCHGNC:1318EnsemblENSG00000125730NCBI Gene718
Locus: gene with protein productLocation: 19p13.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Complement C3P01024

Protein · therapeutic target

Clinically validated target · 1 approved medicine against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCPAMD1 · ARMD9 · C3a · C3b
View full nomenclature history (9)
Alias symbolsCPAMD1, ARMD9, C3a, C3b
Previous namescomplement component 3
Alias namesC3a anaphylatoxin, complement component C3a, complement component C3b, prepro-C3

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Macular Degeneration
Retinal Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Receptor ligandsC3 and PZP like, alpha-2-macroglobulin domain containingComplement system activation components

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2025-09-04.
Open TargetsGene–disease associations from the Open Targets Platform.