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C5

Gene

complement C5

HGNCHGNC:1331EnsemblENSG00000106804NCBI Gene727
Locus: gene with protein productLocation: 9q33.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Complement C5P01031

Protein · therapeutic target

Clinically validated target · 8 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCPAMD4 · C5a · C5b
View full nomenclature history (6)
Alias symbolsCPAMD4, C5a, C5b
Previous namescomplement component 5
Alias namesC5a anaphylatoxin, prepro-C5

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Myasthenia Gravis
Neuromyelitis Optica
Macular Degeneration

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Receptor ligandsC3 and PZP like, alpha-2-macroglobulin domain containingComplement system activation componentsMembrane Attack complex

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-07-26.
Open TargetsGene–disease associations from the Open Targets Platform.