C5AR1

Gene

complement C5a receptor 1

HGNCHGNC:1338 EnsemblENSG00000197405 NCBI Gene728

Locus: gene with protein productLocation: 19q13.32

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

C5a anaphylatoxin chemotactic receptor 1P21730

Protein · therapeutic target

Clinically validated target · 1 approved medicine against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asC5R1 · C5A · C5AR · CD88

View full nomenclature history (6)

Previous symbolsC5R1

Alias symbolsC5A, C5AR, CD88

Previous namescomplement component 5 receptor 1 (C5a ligand), complement component 5a receptor 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Granulomatosis with polyangiitis

Nephritis

Neoplasms

COVID-19

Respiratory Distress Syndrome

Alzheimer's Disease

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Complement component GPCRsCD moleculesComplement system regulators and receptors

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.