CACNA1C

Gene

calcium voltage-gated channel subunit alpha1 C

HGNCHGNC:1390 EnsemblENSG00000151067 NCBI Gene775

Locus: gene with protein productLocation: 12p13.33

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Voltage-dependent L-type calcium channel subunit alpha-1CQ13936

Protein · therapeutic target

Clinically validated target · 36 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCCHL1A1 · CACNL1A1 · CACNA1C-IT2 · LQT8 · TS · Cav1.2 · CACH2 · CACN2

View full nomenclature history (11)

Previous symbolsCCHL1A1, CACNL1A1, CACNA1C-IT2

Alias symbolsLQT8, TS, Cav1.2, CACH2, CACN2

Previous namescalcium channel, voltage-dependent, L type, alpha 1C subunit, CACNA1C intronic transcript 2, CACNA1C intronic transcript 2 (non-protein coding)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures

Brugada syndrome

acquired long QT syndrome

Epilepsy

Diabetes Mellitus

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Calcium voltage-gated channel alpha1 subunits

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-03.

Open TargetsGene–disease associations from the Open Targets Platform.