CACNB2

Gene

calcium voltage-gated channel auxiliary subunit beta 2

HGNCHGNC:1402 EnsemblENSG00000165995 NCBI Gene783

Locus: gene with protein productLocation: 10p12

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Voltage-dependent L-type calcium channel subunit beta-2Q08289

Protein · therapeutic target

Clinically validated target · 7 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asMYSB · CACNLB2

View full nomenclature history (3)

Previous symbolsMYSB, CACNLB2

Previous namescalcium channel, voltage-dependent, beta 2 subunit

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Epilepsy

Cardiovascular Diseases

Brugada syndrome

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Membrane associated guanylate kinasesCalcium voltage-gated channel auxiliary beta subunits

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.