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CASP1

Gene

caspase 1

HGNCHGNC:1499EnsemblENSG00000137752NCBI Gene834
Locus: gene with protein productLocation: 11q22.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Caspase-1P29466

Protein · therapeutic target

Clinical-stage target · 3 candidates in clinical development

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asIL1BC · ICE
View full nomenclature history (7)
Previous symbolsIL1BC
Alias symbolsICE
Previous namescaspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase), caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase), caspase 1, apoptosis-related cysteine peptidase
Alias namescaspase-1, interleukin 1, beta, convertase

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Severe Acute Respiratory Syndrome
Infections
Neoplasms
COVID-19
Major depressive disorder
Carcinoma, Hepatocellular
Diabetes Mellitus, Type 2

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CaspasesCaspase recruitment domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.