CASP3

Gene

caspase 3

HGNCHGNC:1504 EnsemblENSG00000164305 NCBI Gene836

Locus: gene with protein productLocation: 4q35.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Caspase-3P42574

Protein · therapeutic target

Clinical-stage target · 1 candidate in clinical development

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCPP32 · CPP32B · Yama · apopain

View full nomenclature history (6)

Alias symbolsCPP32, CPP32B, Yama, apopain

Previous namescaspase 3, apoptosis-related cysteine protease, caspase 3, apoptosis-related cysteine peptidase

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases

Mucocutaneous Lymph Node Syndrome

Carcinoma, Hepatocellular

Breast Neoplasms

Lung carcinoma

Leukemia, Myeloid, Acute

Small Cell Lung Carcinoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CaspasesSmall nucleolar RNA protein coding host genes

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.