Protein / target

Caspase-3

CASP3P42574
UniProt: P42574
17
Research papers

Protein at a glance

Research activity

Emerging research

17 papers · latest 2025

Derived from structured UniProt, Open Targets and literature data on this page.

Research activity

17 papers · to 2025

Papers linked directly to this protein. This is the protein's own literature — descriptor-derived papers are kept separate below.

Most cited

Cellular survival: a play in three Akts.3,130 cites

Datta SR · Genes & development · 1999

The roles of segmental and tandem gene duplication in the evolution of large gene families in Arabidopsis thaliana.1,466 cites

Cannon SB · BMC plant biology · 2004

Cell Death Signaling.790 cites

Green DR · Cold Spring Harbor perspectives in biology · 2015

Caspases in Cell Death, Inflammation, and Pyroptosis.740 cites

Kesavardhana S · Annual review of immunology · 2020

APP processing in Alzheimer's disease.684 cites

Zhang YW · Molecular brain · 2011

Recent

Nonapoptotic caspase-3 guides C1q-dependent synaptic phagocytosis by microglia.

Andoh M · Nature communications · 2025

Innate and adaptive immune cell interaction drives inflammasome activation and hepatocyte apoptosis in murine liver injury from immune checkpoint inhibitors.

Shojaie L · Cell death & disease · 2024

Therapeutic potential of PANoptosis: innate sensors, inflammasomes, and RIPKs in PANoptosomes.

Pandeya A · Trends in molecular medicine · 2024

Epigallocatechin gallate improves neuronal damage in animal model of ischemic stroke and glutamate-exposed neurons via modulation of hippocalcin expression.

Park DJ · PloS one · 2024

Regeneration and Plasticity Induced by Epidural Stimulation in a Rodent Model of Spinal Cord Injury.

Angelin LG · International journal of molecular sciences · 2024

Neuronal-specific TNFAIP1 ablation attenuates postoperative cognitive dysfunction via targeting SNAP25 for K48-linked ubiquitination.

Wang W · Cell communication and signaling : CCS · 2023

The multifaceted roles of GSDME-mediated pyroptosis in cancer: therapeutic strategies and persisting obstacles.

Hu Y · Cell death & disease · 2023

Apoptosis and its pathways as targets for intracellular pathogens to persist in cells.

Rodríguez-González J · Parasitology research · 2023

Copper metabolism in cell death and autophagy.

Xue Q · Autophagy · 2023

Immune gene signatures for predicting durable clinical benefit of anti-PD-1 immunotherapy in patients with non-small cell lung cancer.

Hwang S · Scientific reports · 2020

Europe PMC papers linked directly to this protein.