CBLB

Gene

Cbl proto-oncogene B

HGNCHGNC:1542 EnsemblENSG00000114423 NCBI Gene868

Locus: gene with protein productLocation: 3q13.11

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asRNF56 · Cbl-b

View full nomenclature history (5)

Alias symbolsRNF56, Cbl-b

Previous namesCas-Br-M (murine) ectropic retroviral transforming sequence b, Cas-Br-M (murine) ecotropic retroviral transforming sequence b, Cbl proto-oncogene B, E3 ubiquitin protein ligase

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Carcinoma, Pancreatic Ductal

Lung carcinoma

Carcinoma of liver and intrahepatic biliary tract

Lymphoid neoplasm

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Ring finger proteins

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2024-09-23.

Open TargetsGene–disease associations from the Open Targets Platform.