Disease

Myxedema

Associated genes

Related proteins

Current focus

Thyrotropin biologyToll-like 3 biologyInflammation & immunity

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

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Associated genes

12 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

TSHR0.61 IFIH10.56 TLR30.46 VAV30.45 CHRNA90.45 CD2260.43 ADCY70.42 SYN20.42 CBLB0.42 NFATC10.42 TNFRSF140.41 STAT40.41

Disease biology

8 matches

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Thyrotropin receptorvia TSHR0.61 Interferon-induced helicase C domain-containing protein 1via IFIH10.56 Toll-like receptor 3via TLR30.46 Tumor necrosis factor receptor superfamily member 11Bvia TNFRSF11B0.38 Excitatory amino acid transporter 2via SLC1A20.36 Interferon gammavia IFNG0.35 Interleukin-21via IL210.29 Interferon regulatory factor 7via IRF70.19

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

A condition characterized by a dry, waxy type of swelling (EDEMA) with abnormal deposits of MUCOPOLYSACCHARIDES in the SKIN and other tissues. It is caused by a deficiency of THYROID HORMONES. The skin becomes puffy around the eyes and on the cheeks. The face is dull and expressionless with thickened nose and lips.

References & data sources

Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
Related entities are derived from literature co-mention (studied together) — associative, not causal.