VAV3

Gene

vav guanine nucleotide exchange factor 3

HGNCHGNC:12659 EnsemblENSG00000134215 NCBI Gene10451

Locus: gene with protein productLocation: 1p13.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

View full nomenclature history (2)

Previous namesvav 3 oncogene, vav 3 guanine nucleotide exchange factor

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Hypothyroidism

Leishmaniasis, Cutaneous

Thyroid Diseases

Hashimoto's Disease

Myxedema

Thyroid gland carcinoma

Neurodegenerative Diseases

Autoimmune Diseases

Alcohol drinking

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Pleckstrin homology domain containingDbl family Rho GEFsSH2 domain containingMicroRNA protein coding host genes

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2024-01-16.

Open TargetsGene–disease associations from the Open Targets Platform.