CD33

Gene

CD33 molecule

HGNCHGNC:1659 EnsemblENSG00000105383 NCBI Gene945

Locus: gene with protein productLocation: 19q13.41

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Myeloid cell surface antigen CD33P20138

Protein · therapeutic target

Clinically validated target · 1 approved medicine against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asSIGLEC3 · SIGLEC-3 · p67 · FLJ00391 · CD33rSiglec

View full nomenclature history (7)

Alias symbolsSIGLEC3, SIGLEC-3, p67, FLJ00391, CD33rSiglec

Previous namesCD33 antigen (gp67)

Alias namessialic acid binding Ig-like lectin 3

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Leukemia, Myeloid, Acute

Alzheimer's Disease

Acute promyelocytic leukemia

Leukemia, Myeloid

Neoplasms

Dengue

Myelodysplastic syndrome

Parkinson's Disease

Neurodegenerative Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD moleculesV-set domain containingSialic acid binding Ig like lectins

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2024-02-01.

Open TargetsGene–disease associations from the Open Targets Platform.