CD40LG

Gene

CD40 ligand

HGNCHGNC:11935 EnsemblENSG00000102245 NCBI Gene959

Locus: gene with protein productLocation: Xq26.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

CD40 ligandP29965

Protein · therapeutic target

Clinical-stage target · 6 candidates in clinical development

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asIMD3 · TNFSF5 · HIGM1 · CD40L · TRAP · gp39 · hCD40L · CD154 · CD40-L · T-BAM

View full nomenclature history (16)

Previous symbolsIMD3, TNFSF5

Alias symbolsHIGM1, CD40L, TRAP, gp39, hCD40L, CD154, CD40-L, T-BAM

Previous namestumor necrosis factor (ligand) superfamily, member 5 (hyper-IgM syndrome)

Alias namesCD40 antigen ligand, tumor necrosis factor (ligand) superfamily member 5, T-B cell-activating molecule, TNF-related activation protein, hyper-IgM syndrome

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Genetic Diseases, Inborn

Lupus Erythematosus, Systemic

Common variable immunodeficiency

Sjogren's Syndrome

Neurodegenerative Diseases

Colitis, Ulcerative

Sarcoidosis

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD moleculesTumor necrosis factor superfamily

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.