CD80

Gene

CD80 molecule

HGNCHGNC:1700 EnsemblENSG00000121594 NCBI Gene941

Locus: gene with protein productLocation: 3q13.33

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

T-lymphocyte activation antigen CD80P33681

Protein · therapeutic target

Clinically validated target · 2 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCD28LG · CD28LG1 · B7.1 · B7-1

View full nomenclature history (7)

Previous symbolsCD28LG, CD28LG1

Alias symbolsB7.1, B7-1

Previous namesCD80 antigen (CD28 antigen ligand 1, B7-1 antigen), CD80 molecule

Alias namesB-lymphocyte activation antigen B7

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Arthritis, Rheumatoid

Arthritis, Juvenile

Arthritis, Psoriatic

Immune System Diseases

Hypothyroidism

Neoplasms

Kidney transplant

Lupus Erythematosus, Systemic

Lymphoma, Non-Hodgkin's

Sjogren's Syndrome

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD moleculesV-set domain containingC2-set domain containingB7 family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.