CD86

Gene

CD86 molecule

HGNCHGNC:1705 EnsemblENSG00000114013 NCBI Gene942

Locus: gene with protein productLocation: 3q13.33

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

T-lymphocyte activation antigen CD86P42081

Protein · therapeutic target

Clinically validated target · 2 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCD28LG2 · B7.2 · B7-2

View full nomenclature history (5)

Previous symbolsCD28LG2

Alias symbolsB7.2, B7-2

Previous namesCD86 antigen (CD28 antigen ligand 2, B7-2 antigen)

Alias namesB-lymphocyte antigen B7-2

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Arthritis, Rheumatoid

Arthritis, Juvenile

Multiple Sclerosis

Arthritis, Psoriatic

Immune System Diseases

Hypothyroidism

Neoplasms

Kidney transplant

Neurodegenerative Diseases

Lymphoma, Non-Hodgkin's

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD moleculesV-set domain containingB7 family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.