CDKN1A

Gene

cyclin dependent kinase inhibitor 1A

HGNCHGNC:1784 EnsemblENSG00000124762 NCBI Gene1026

Locus: gene with protein productLocation: 6p21.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Cyclin-dependent kinase inhibitor 1P38936

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCDKN1 · P21 · CIP1 · WAF1 · SDI1 · CAP20 · p21CIP1 · p21Cip1/Waf1

View full nomenclature history (11)

Previous symbolsCDKN1

Alias symbolsP21, CIP1, WAF1, SDI1, CAP20, p21CIP1, p21Cip1/Waf1

Previous namescyclin-dependent kinase inhibitor 1A (p21, Cip1)

Alias namesp21 cdkn, Cdk-interacting protein 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Urinary Bladder Neoplasms

Neurodegenerative Diseases

Alzheimer's Disease

Parkinson's Disease

Atrial Fibrillation

Lysosomal Storage Diseases

Multiple Sclerosis

Heart Failure

Cardiomyopathy, Hypertrophic

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Cyclin dependent kinase inhibitor 1 family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2026-06-30.

Open TargetsGene–disease associations from the Open Targets Platform.