Back to discover

CFI

Gene

complement factor I

HGNCHGNC:5394EnsemblENSG00000205403NCBI Gene3426
Locus: gene with protein productLocation: 4q25

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asIF · FI · C3b-INA · C3bINA · KAF
View full nomenclature history (8)
Previous symbolsIF
Alias symbolsFI, C3b-INA, C3bINA, KAF
Previous namesI factor (complement)
Alias namesKonglutinogen-activating factor, C3b-inactivator

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Macular Degeneration
Retinal Diseases
COVID-19

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Serine proteasesScavenger receptor cysteine rich domain containingComplement system regulators and receptors

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2025-07-14.
Open TargetsGene–disease associations from the Open Targets Platform.