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CHEK2

Gene

checkpoint kinase 2

HGNCHGNC:16627EnsemblENSG00000183765NCBI Gene11200
Locus: gene with protein productLocation: 22q12.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asRAD53 · CDS1 · CHK2 · HuCds1 · PP1425 · bA444G7
View full nomenclature history (8)
Previous symbolsRAD53
Alias symbolsCDS1, CHK2, HuCds1, PP1425, bA444G7
Previous namesCHK2 (checkpoint, S.pombe) homolog, CHK2 checkpoint homolog (S. pombe)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Breast Neoplasms
Neoplasms
Li-Fraumeni Syndrome
Prostatic Neoplasms
Familial prostate cancer

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Checkpoint kinase 2 family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.