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CIITA

Gene

class II major histocompatibility complex transactivator

HGNCHGNC:7067EnsemblENSG00000179583NCBI Gene4261
Locus: gene with protein productLocation: 16p13.13

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asMHC2TA · C2TA · NLRA
View full nomenclature history (7)
Previous symbolsMHC2TA
Alias symbolsC2TA, NLRA
Previous namesMHC class II transactivator, class II, major histocompatibility complex, transactivator
Alias namesNLR family, acid domain containing, nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Arthritis, Rheumatoid
Melanoma
Inflammatory Bowel Diseases
Lung carcinoma
Gastric carcinoma
Cutaneous melanoma
Hemangioblastoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

NLR family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.