CR1

Gene

complement C3b/C4b receptor 1 (Knops blood group)

HGNCHGNC:2334 EnsemblENSG00000203710 NCBI Gene1378

Locus: gene with protein productLocation: 1q32.2

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCD35 · KN

View full nomenclature history (5)

Alias symbolsCD35, KN

Previous namescomplement component (3b/4b) receptor 1, including Knops blood group system, complement component (3b/4b) receptor 1 (Knops blood group), complement component 3b/4b receptor 1 (Knops blood group)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Alzheimer's Disease

Dementia

late-onset Alzheimers disease

Neurodegenerative Diseases

Hypothyroidism

Lupus Erythematosus, Systemic

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Blood group antigensCD moleculesSushi domain containingComplement system regulators and receptors

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-15.

Open TargetsGene–disease associations from the Open Targets Platform.