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CSF1R

Gene

colony stimulating factor 1 receptor

HGNCHGNC:2433EnsemblENSG00000182578NCBI Gene1436
Locus: gene with protein productLocation: 5q32

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Macrophage colony-stimulating factor 1 receptorP07333

Protein · therapeutic target

Clinically validated target · 7 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asFMS · M-CSF-R · C-FMS · CSFR · CD115
View full nomenclature history (7)
Previous symbolsFMS
Alias symbolsM-CSF-R, C-FMS, CSFR, CD115
Previous namesMcDonough feline sarcoma viral (v-fms) oncogene homolog
Alias namesmacrophage colony-stimulating factor 1 receptor

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Leukoencephalopathy, diffuse hereditary, with spheroids 1
Hereditary diffuse leukoencephalopathy with axonal spheroids and pigmented glia
Brain abnormalities, neurodegeneration, and dysosteosclerosis
Gastrointestinal Stromal Tumors
Carcinoma, Renal Cell
Neoplasms
Leukoencephalopathy, hereditary diffuse, with spheroids
Tenosynovial giant cell tumor, diffuse type
Neuroendocrine Tumors
Soft tissue sarcoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD moleculesImmunoglobulin like domain containingCSF1R, KIT, FLT3 receptor tyrosine kinase family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2026-06-25.
Open TargetsGene–disease associations from the Open Targets Platform.