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CXCL8

Gene

C-X-C motif chemokine ligand 8

Locus: gene with protein productLocation: 4q13.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asIL8 · SCYB8 · LUCT · LECT · MDNCF · TSG-1 · IL-8 · NAP-1 · 3-10C · MONAP · AMCF-I · LYNAP · NAF · b-ENAP · GCP-1 · K60 · GCP1 · NAP1
View full nomenclature history (29)
Previous symbolsIL8
Alias symbolsSCYB8, LUCT, LECT, MDNCF, TSG-1, IL-8, NAP-1, 3-10C, MONAP, AMCF-I, LYNAP, NAF, b-ENAP, GCP-1, K60, GCP1, NAP1
Previous namesinterleukin 8, chemokine (C-X-C motif) ligand 8
Alias namesneutrophil-activating peptide 1, granulocyte chemotactic protein 1, lung giant cell carcinoma-derived chemotactic protein, tumor necrosis factor-induced gene 1, monocyte-derived neutrophil-activating peptide, lymphocyte derived neutrophil activating peptide, beta endothelial cell-derived neutrophil activating peptide, alveolar macrophage chemotactic factor I, monocyte-derived neutrophil chemotactic factor

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Chemokine ligandsInterleukins

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.