CYBB

Gene

cytochrome b-245 beta chain

HGNCHGNC:2578 EnsemblENSG00000165168 NCBI Gene1536

Locus: gene with protein productLocation: Xp21.1-p11.4

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

NADPH oxidase 2P04839

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCGD · GP91-PHOX · NOX2 · GP91PHOX · p91-PHOX

View full nomenclature history (10)

Previous symbolsCGD

Alias symbolsGP91-PHOX, NOX2, GP91PHOX, p91-PHOX

Previous nameschronic granulomatous disease, cytochrome b-245, beta polypeptide

Alias namesNADPH oxidase 2, Cytochrome b-245 heavy chain, Cytochrome b558 subunit beta

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Granulomatous Disease, Chronic

Neurodegenerative Diseases

Genetic Diseases, Inborn

Kartagener Syndrome

Diabetes Mellitus

Lupus Erythematosus, Systemic

Neoplasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

FlavoproteinsNADH oxidase family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-07-21.

Open TargetsGene–disease associations from the Open Targets Platform.