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DDX1

Gene

DEAD-box helicase 1

HGNCHGNC:2734EnsemblENSG00000079785NCBI Gene1653
Locus: gene with protein productLocation: 2p24.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asTSLIG6 · DBP-RB
View full nomenclature history (7)
Alias symbolsTSLIG6, DBP-RB
Previous namesDEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 1, DEAD (Asp-Glu-Ala-Asp) box polypeptide 1, DEAD (Asp-Glu-Ala-Asp) box helicase 1
Alias namesDEAD-box RNA helicase DDX1, DEAD-box protein retinoblastoma

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases
Gout
Wilms Tumor
Alzheimer's Disease
Lysosomal Storage Diseases
Multiple Sclerosis
Parkinson's Disease

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

DEAD-box helicasestRNA splicing ligase complex

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2026-06-08.
Open TargetsGene–disease associations from the Open Targets Platform.