DEFA5

Gene

defensin alpha 5

HGNCHGNC:2764 EnsemblENSG00000164816 NCBI Gene1670

Locus: gene with protein productLocation: 8p23.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asDEF5 · HD-5

View full nomenclature history (3)

Previous symbolsDEF5

Alias symbolsHD-5

Previous namesdefensin, alpha 5, Paneth cell-specific

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Glomerulonephritis, IGA

Neoplasms

Inflammatory Bowel Diseases

Intestinal Diseases

Enterocolitis, Necrotizing

Obesity due to melanocortin 4 receptor deficiency

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Defensins, alpha

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.