DIS3

Gene

DIS3 exosome endoribonuclease and 3'-5' exoribonuclease

HGNCHGNC:20604 EnsemblENSG00000083520 NCBI Gene22894

Locus: gene with protein productLocation: 13q21.33

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asdis3p · RRP44 · EXOSC11

View full nomenclature history (7)

Alias symbolsdis3p, RRP44, EXOSC11

Previous namesKIAA1008, DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease, DIS3 mitotic control homolog (S. cerevisiae)

Alias namesexosome component 11

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Multiple Myeloma

Self-injurious ideation

COVID-19

Hidradenitis Suppurativa

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Exosome complexEndoribonucleasesPIN-like domain superfamily

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2025-10-10.

Open TargetsGene–disease associations from the Open Targets Platform.