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DKK3

Gene

dickkopf Wnt signaling pathway inhibitor 3

HGNCHGNC:2893EnsemblENSG00000050165NCBI Gene27122
Locus: gene with protein productLocation: 11p15.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asREIC · RIG · CRRL
View full nomenclature history (8)
Alias symbolsREIC, RIG, CRRL
Previous namesdickkopf WNT signaling pathway inhibitor 3, dickkopf (Xenopus laevis) homolog 3, dickkopf 3 homolog (Xenopus laevis)
Alias namesregulated in glioma, cardiomyocyte regeneration-related lncRNA

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Hypothyroidism
Adverse effect
Bladder calculus
Diabetes Mellitus
Polycystic Kidney, Autosomal Dominant

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Dickkopf family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2025-06-27.
Open TargetsGene–disease associations from the Open Targets Platform.